Iron deficiency and NRAMP1 polymorphisms (INT4, D543N and 3′UTR) do not contribute to severity of anaemia in tuberculosis in the Indonesian population

Fe-deficiency anaemia is the most common cause of anaemia in developing countries. In these settings, many chronic infections, including tuberculosis (TB), are highly prevalent. Fe is an essential nutrient for both host and mycobacteria that play a pivotal role in host immunity and mycobacterial growth. A case–control study was performed in a TB-endemic region in Jakarta, Indonesia, among 378 pulmonary TB patients and 436 healthy controls from the same neighbourhood with the same socio-economic status. In a number of these subjects the Fe status could be explored. The distribution of three polymorphisms in the natural resistance-associated macrophage protein gene (NRAMP1) including INT4, D543N and 3′UTR was examined for a possible association with susceptibility to TB. Anaemia (corrected for sex) was present in 63·2 % of active TB compared with 6·8 % of controls, with female patients more often affected. Anaemia was more pronounced in advanced TB as diagnosed by chest radiography. Lower Hb concentrations in TB patients were accompanied by lower plasma Fe concentrations, lower Fe-binding capacity and higher plasma ferritin. After successful TB therapy, Fe parameters improved towards control values and Hb levels normalised, even without Fe supplementation. NRAMP1 gene polymorphisms were not associated with TB susceptibility, TB severity or anaemia. In conclusion, most active TB patients had anaemia, which was probably due to inflammation and not to Fe deficiency since TB treatment without Fe supplementation was sufficient to restore Hb concentration. … celý popis

Podrobná bibliografie

Publikováno v

British journal of nutrition Ročník 98; číslo 4; s. 684 - 690

Hlavní autoři

Sahiratmadja, Edhyana, Wieringa, Frank T., van Crevel, Reinout, de Visser, Adriëtte W., Adnan, Iskandar, Alisjahbana, Bachti, Slagboom, Eline, Marzuki, Sangkot, Ottenhoff, Tom H. M., van de Vosse, Esther, Marx, Joannes J. M.

Typ dokumentu

Journal Article

Jazyk

English

Vydáno

Cambridge, UK Cambridge University Press 01. 10. 2007

Témata

méně…

Adolescent

Adult

Aged

Anaemia

Anemia, Iron-Deficiency - genetics

Biological and medical sciences

C-reactive protein

Case-Control Studies

Cation Transport Proteins - genetics

Chronic illnesses

Developing countries

Feeding. Feeding behavior

Female

Fundamental and applied biological sciences. Psychology

Genetic disorders

Genetic Predisposition to Disease

Humans

Indonesia

Infectious diseases

Iron

Iron - deficiency

LDCs

Male

Middle Aged

Mycobacterium

NRAMP1

Nutrient deficiency

Patients

Plasma

Polymorphism, Genetic

Radiography

Risk factors

Socioeconomics

Studies

Tuberculosis

Tuberculosis, Pulmonary - genetics

Vertebrates: anatomy and physiology, studies on body, several organs or systems

Asia

Indonesia

Iron

Tuberculosis

C-reactive protein

Anaemia

NRAMP1

Tuberculosis: C-reactive protein: Anaemia: Iron: NRAMP1

Iron deficiency anemia

Metabolic diseases

Hemopathy

Mycobacterial infection

Inorganic element

Infection

Vertebrata

Mammalia

Bacteriosis

Population

Sideropenia

C reactive protein

Polymorphism

více… méně…

Bibliografie

istex:4977C4CCB4AB40B24F5FA84A14E59F487FF30740
PII:S0007114507742691
ark:/67375/6GQ-SN4LW7XF-H
Abbreviations: ACD, anaemia of chronic disease; CRP, C-reactive protein; CXR, chest X-ray radiography; ESR, erythrocyte sedimentation rate; MCH, mean corpuscular Hb; MCV, mean corpuscular volume; MTB, Mycobacterium tuberculosis; NRAMP1, natural resistance-associated macrophage protein; TB, tuberculosis
ArticleID:74269
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23

ISSN

0007-1145
1475-2662

DOI

10.1017/S0007114507742691