IL-28 and IL-29 as protective markers in subject with dengue fever
About 400 million people every year are estimated to contract dengue virus infection, which causes prolonged morbidity and sometimes mortality. Interleukin (IL)-28 and IL-29 are relatively newly discovered cytokines and play an important role in our immune defense against pathogens, especially for viral infection. In the present study, we investigated serum
IL-28 and IL-29 expression and the relationship to clinical and laboratory parameters in patients with dengue virus infection. Adult patients with dengue (
n
= 45) and control group (
n
= 24) were included prospectively. Clinical symptoms and laboratory data were collected from every patient. We investigated IL-28 and IL-29 levels in serum by ELISA. The concentrations of serum IL-28 and IL-29 were significantly higher in subjects with dengue when compared to those of control group. The patients with higher serum IL-28 and IL-29 levels had significantly lower ALAT and peripheral blood neutrophil percentage, but higher peripheral platelet, total white blood cell (WBC), monocyte, and lymphocyte counts. Patients with higher serum IL-28 and IL-29 levels also had more flu-like symptoms, but less vomiting. Increased level of IL-28 and IL-29 was associated with better liver function, platelet and WBC numbers and clinical symptom in subjects with dengue and could potentially serve as a protective marker.
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Podrobná bibliografie
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Publikováno v
- Medical microbiology and immunology
Ročník 206; číslo 3; s. 217 - 223
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Hlavní autoři
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Hung, Chih-Hsing,
Huang, Chung-Hao,
Wang, Lin,
Huang, Chun-Chi,
Wu, Meng-Chieh,
Chin, Yi-Ying,
Lin, Chun-Yu,
Chang, Ko,
Wu, Deng-Chyang,
Chen, Yen-Hsu
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Typ dokumentu
- Journal Article
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Jazyk
- English
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Vydáno
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Berlin/Heidelberg
Springer Berlin Heidelberg
01. 06. 2017
Springer Nature B.V
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Témata
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Bibliografie
- ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
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ISSN
- 0300-8584
1432-1831
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DOI
- 10.1007/s00430-017-0498-x
