Návrh štruktúry, syntéza a biologická aktivita nových karbamátových inhibítorov cholínesteráz = Design, Synthesis and Biological Activity of New Carbamate Cholinesterase Inhibitors

To chci

The work deals with the design, synthesis and biological activity of new carbamate cholinesterase inhibitors. It is focused on selected syntheses of new carbamate derivatives, which were tested for their anticholinesterase activity against acetylcholinesterase as well as butyrylcholinesterase. Despite various theories in the pathogenesis of Alzheimer's disease, drugs that can inhibit these two enzymes still represent the major approach to the treatment of this neurodegenerative disease. Many of the newly synthesized compounds have unique chemical structure. Recently, the approach to the synthesis of new cholinesterase inhibitors has focused on the preparation of potential drugs, containing in their chemical structure fragments of already known drugs, commonly used in the pharmacotherapy of Alzheimer's disease, but also other diseases. The aim of preparing these compounds is to affect several biological systems simultaneously. These multipotent compounds have been termed "multi-target-directed ligands"; the molecules of drugs used to treat Alzheimer's disease always contain a pharmacophore acting as a cholinesterase inhibitor, which represents the mainstay of therapy. … celý popis

Podrobná bibliografie

Hlavní autor

Lucia Ungvarská Maľučká

Další autoři

Jozef Csöllei

Typ dokumentu

Články

Fyzický popis

14 ilustrací

Publikováno v

Chemické listy. -- ISSN 0009-2770. -- Roč. 116, č. 6 (2022), s. 372-380

Témata

BRAIN

ATROPHY

Neuropathy

Memory

LESIONS

DRUGS

ENZYME INHIBITORS

CHOLINESTERASE

SIDE EFFECTS

TOXICITY

CARBAMATES

mozek

atrofie

neuropatie

paměť

léze

léky

inhibitory enzymů

cholinesteráza

vedlejší účinky

toxicita

karbamáty

neurodegenerativní onemocnění > Alzheimerova choroba > demence > kognitivní funkce > piperidin > chalkon > ladostigil > rivastigmin > fluoxetin > multifunkčně zaměřené látky

Popis jednotky

14 obrázků

Bibliografie

Literatura na s. 379 (37 zázn.)