Gonadoliberin (gonadotropin uvolňující hormon), jeho agonisté a antagonisté = Gonadoliberin (Gonadotropin-Releasing Hormone), Its Agonists and Antagonists

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Nowadays, analogues of gonadotropin-releasing hormone are among the standard drugs in several indications, often using modern dosage forms. Globally, their market is estimated at billions of $ annually. This review article summarizes basic information on the relationship between structure and effect, pharmacology, and application of gonadotropin-releasing hormone and its synthetic analogues. Due to their properties, namely a higher efficiency and a higher binding affinity for the gonadotropin-releasing hormone receptor compared to native gonadotropin releasing hormone, the analogues have found applications in the treatment of many diseases, where it is necessary to suppress the secretion of gonadotropins and sex hormones. They are usually indicated for the treatment of cancers of various origins, premature puberty or artificial insemination. Due to their peptide nature, they are not administered orally, but require injection or intranasal administration. Compared to agonists, antagonists show faster onset of action and the absence of the so-called flare-up phenomenon, i.e., temporarily increased serum levels of lutropin, follitropin and, consequently, of testosterone and estradiol. … full description

Bibliographic Details

Main Author

Martina Holická

Other Authors

Jakub Vysloužil , Kateřina Kubová , Jan Muselík , David Vetchý, 1972-

Document Type

Articles

Physical Description

3 ilustrace

Published in

Chemické listy. -- ISSN 0009-2770. -- Roč. 115, č. 10 (2021), s. 516-523

Subjects

SEXUAL REPRODUCTION

REPRODUCTIVE PERFORMANCE

SEX HORMONES

GONADOTROPINS

GNRH

RELEASING HORMONES

Hormone agonists

HORMONE ANTAGONISTS

REPRODUCTIVE DISORDERS

THERAPY

DRUGS

FORMULATIONS

DOSAGE EFFECTS

pohlavní rozmnožování

reprodukční schopnost

pohlavní hormony

gonadotropiny

GnRH

spouštěcí hormony

agonisté hormonů

antagonisté hormonů

poruchy reprodukce

terapie

léky

formy

účinnost dávky

alarelin > leuprorelin > triptorelin > goserelin > buserelin > nafarelin > deslorelin > veterinární léčiva > cetrorelix > ganirelix > degarelix > asistovaná reprodukce

Item Description

3 tabulky

Bibliography

Literatura na s. 521-523 (72 zázn.)