Lékové formy vinanu zolpidemu = Dosage Forms of Zolpidem Tartrate

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Insomnia is one of the long-term problems that afflict a major part of the population. The high incidence of the disorder and its health consequences are alarming. In the medical treatment of insomnia, z-hypnotics, especially zolpidem, are most used. Drug zolpidem as a selective agonist has a high affinity for α1 subunit of the GABAA receptor. Only zolpidem tartrate is used for the formulation of dosage forms. In the US, a number of zolpidem dosage forms have become available. These novel dosage forms enhance the pharmacokinetic profile of oral immediate release tablets and facilitate the administration. Among them, there are oral controlled release tablets, sublingual tablets, orally dispersible tablets and oral spray. The development of alternative dosage forms increases the therapeutic options available to patients. … full description

Bibliographic Details

Main Author

Lucie Gruberová

Other Authors

Bohumil Kratochvíl, 1949-

Document Type

Articles

Physical Description

8 ilustrací

Published in

Chemické listy. -- ISSN 0009-2770. -- Roč. 112, č. 11 (2018), s. 734-740

Subjects

SLEEP

DISORDERS

DRUG THERAPY

PHARMACOLOGY

STRUCTURE ACTIVITY RELATIONSHIPS

MODE OF ACTION

DRUGS

DOSAGE

Pharmacokinetics

Pharmacodynamics

NEUROTRANSMITTERS

Receptors

spánek

poruchy

léčba léky

farmakologie

chemická struktura

vztahy struktura-působení

způsob působení

léky

dávkování

farmakokinetika

farmakodynamika

neurotransmitery

receptory

insomnie > vinan zolpidemu > sublinguální tablety > orálně dispergovatelné tablety > orální sprej > z-hypnotika > nespavost > GABA > řízené uvolňování

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Item Description

3 grafy, 3 obrázky, 2 tabulky

Bibliography

Literatura na s. 739-740 (50 zázn.)