Syntéza proteinkinasových inhibitorů

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Two procedures have been developed for the synthesis of sorafenib tosylate. The aim of the development was to minimize production of symmetric ureas in the course of synthesis, which create the major impurities of the preceeding processes and are difficult to remove. The major achievements were the purity of sorafenib thus obtained (< 99.8 %, HPLC) and possibility … full description

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Bibliographic Details

Main Author
Francesca Scarpitta
Other Authors
Augusto Canavesi
Alexandr Jegorov
Document Type
Articles
Physical Description
6 il.
Published in
Chemické listy. -- ISSN 0009-2770. -- Roč. 105, č. 4 (2011), s. 278-281
Subjects
ENZYME INHIBITORS
ENZYMES
PROTEIN KINASE
inhibitory enzymů
enzymy
Item Description
Schemata
Bibliography
Literatura na s. 281 (9 zázn.)

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Web záznam v BMČ Bibliographia medica Čechoslovaca
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