Communication and ethical considerations for fertility preservation for patients with childhood, adolescent, and young adult cancer: recommendations from the PanCareLIFE Consortium and the International Late Effects of Childhood Cancer Guideline Harmonization Group

SummaryPatients with childhood, adolescent, and young adult cancer who will be treated with gonadotoxic therapies are at increased risk for infertility. Many patients and their families desire biological children but effective communication about treatment-related infertility risk and procedures for fertility preservation does not always happen. The PanCareLIFE Consortium and the International Late Effects of Childhood Cancer Guideline Harmonization Group reviewed the literature and developed a clinical practice guideline that provides recommendations for ongoing communication methods for fertility preservation for patients who were diagnosed with childhood, adolescent, and young adult cancer at age 25 years or younger and their families. Moreover, the guideline panel formulated considerations of the ethical implications that are associated with these procedures. Grading of Recommendations Assessment, Development and Evaluation methodology was used to grade the evidence and recommendations. In this clinical practice guideline, existing evidence and international expertise are combined to develop transparent recommendations that are easy to use to facilitate ongoing communication between health-care providers and patients with childhood, adolescent, and young adult cancer who might be at high risk for fertility impairment and their families. … full description

Bibliographic Details

Published in

The lancet oncology Vol. 22; no. 2; pp. e68 - e80

Main Authors

Mulder, Renée L, PhD, Font-Gonzalez, Anna, PhD, van Dulmen-den Broeder, Eline, PhD, Quinn, Gwendolyn P, Prof, Ginsberg, Jill P, Prof, Loeffen, Erik A H, PhD, Hudson, Melissa M, MD, Burns, Karen C, MD, van Santen, Hanneke M, PhD, Berger, Claire, MD, Diesch, Tamara, MD, Dirksen, Uta, Prof, Giwercman, Aleksander, Prof, Gracia, Clarisa, MD, Hunter, Sarah E, PhD, Kelvin, Joanne F, MSN, Klosky, James L, Prof, Laven, Joop S E, Prof, Lockart, Barbara A, DNP, Neggers, Sebastian J C M M, PhD, Peate, Michelle, PhD, Phillips, Bob, PhD, Reed, Damon R, MD, Tinner, Eva Maria E, MD, Byrne, Julianne, PhD, Veening, Margreet, PhD, van de Berg, Marleen, PhD, Verhaak, Chris M, PhD, Anazodo, Antoinette, PhD, Rodriguez-Wallberg, Kenny, PhD, van den Heuvel-Eibrink, Marry M, Prof, Asogwa, Ogechukwu A, MSc, Brownsdon, Alexandra, BSc, Wallace, W Hamish, Prof, Green, Daniel M, MD, Skinner, Roderick, FRCPCH, Haupt, Riccardo, MD, Kenney, Lisa B, MD, Levine, Jennifer, MD, van de Wetering, Marianne D, PhD, Tissing, Wim J E, Prof, Paul, Norbert W, Prof, Kremer, Leontien C M, Prof, Inthorn, Julia, PhD

Document Type

Journal Article

Language

English

Published

England Elsevier Ltd 01. 02. 2021
Elsevier Limited

Subjects

Adolescence

Adolescent

Adult

Cancer

Cancer and Oncology

Cancer och onkologi

Cancer Survivors

Child

Childhood

Children

Clinical decision making

Clinical Medicine

Decision making

Disease Progression

Ethics

Female

Fertility Preservation - ethics

Fertility Preservation - trends

Guidelines as Topic

Hematology, Oncology, and Palliative Medicine

Humans

Infertility

Klinisk medicin

Male

Medical and Health Sciences

Medical ethics

Medicin och hälsovetenskap

Neoplasms - complications

Neoplasms - epidemiology

Neoplasms - pathology

Neoplasms - therapy

Patients

Preservation

Teenagers

Young Adult

Young adults

Bibliography

ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1

ISSN

1470-2045
1474-5488

DOI

10.1016/S1470-2045(20)30595-7