Využití analýzy textury při vývoji a hodnocení matricových tablet s prodlouženým uvolňováním léčiva = The Use of Texture Analysis in Development and Evaluation of Matrix Tablets with Prolonged Drug Release

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Texture analysis as a versatile tool for testing the inner structure of materials have been widely used. Though being also used in pharmaceutical industry, it has not been included in standard procedures for evaluation of drug dosage forms. The aim of this study is to measure the thickness of gel layer using texture analysis for the prediction of dissolution profile of very soluble drugs based on hydrophilic and hydrophilic-lipophilic matrix tablets. For the evaluation of the correlation between the thickness of the gel layer as an independent variable and the amount of a released drug as a dependent variable at given time intervals, the multivariate method of partial least squares - PLS-2 regression was used. For the prediction of dissolution characteristics of matrix tablets, a PLS-2 model validated by full cross-validation was developed. … full description

Bibliographic Details

Main Author

Daniel Pěček

Other Authors

Martina Štýbnarová, Eliška Mašková, Petr Doležel, Martina Kejdušová, 1982- , David Vetchý, 1972- , Kateřina Dvořáčková, 1973-

Document Type

Articles

Physical Description

Ilustrace

Published in

Chemické listy. -- ISSN 0009-2770. -- Roč. 108, č. 5 (2014), s. 483-487

Subjects

PHARMACEUTICAL INDUSTRY

DRUGS

FORMULATIONS

PRODUCTION

tabletting

TEXTURE

gels

THICKNESS

MEASUREMENT

POLYMERS

PROCESSING AIDS

DISSOLVING

DATA ANALYSIS

STATISTICAL METHODS

farmaceutický průmysl

léky

formy

výroba

tabletování

textura

gely

tloušťka

měření

polymery

pomocné zpracovatelské prostředky

rozpouštění

prognózování

analýza dat

statistické metody

matricové tablety > hydrofilní matrice > lipofilní matrice > gelová vrstva > uvolňování léčiva > disoluce

Item Description

2 grafy, 1 schéma

Bibliography

Literatura na s. 487,