Modely in vitro - in vivo ve vývoji léčiv = In Vitro - In Vivo Models in Drug Development
Many experiments were performed to obtain in vitro - in vivo correlations for different drugs and formulations. Most of the correlations involve orally administered medical forms and those with prolonged release of the drug. Most of the informative and recommendable in vitro - in vivo correlations are those at level A. If the correlation is not possible, a multiple … celý popis
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- Chemické listy. -- ISSN 0009-2770. -- Roč. 108, č. 1 (2014), s. 32-39
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- 3 grafy, 3 tabulky
- Bibliografie
- Literatura na s. 38-39,
MARC
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| 100 | 1 | |a Vetchý, David, |d 1972- |u Veterinární a farmaceutická univerzita Brno, Farmaceutická fakulta, Ústav technologie léků |7 mzk2006368163 |4 aut | |
| 245 | 1 | 0 | |a Modely in vitro - in vivo ve vývoji léčiv = |b In Vitro - In Vivo Models in Drug Development / |c David Vetchý, Marie Kopecká, Martina Vetchá a Aleš Franc |
| 246 | 3 | 1 | |a In Vitro - In Vivo Models in Drug Development |
| 300 | |b Ilustrace | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a bez média |b n |2 rdamedia | ||
| 338 | |a svazek |b nc |2 rdacarrier | ||
| 500 | |a 3 grafy, 3 tabulky | ||
| 504 | |a Literatura na s. 38-39, |b 25 záznamů | ||
| 520 | 3 | 9 | |a Many experiments were performed to obtain in vitro - in vivo correlations for different drugs and formulations. Most of the correlations involve orally administered medical forms and those with prolonged release of the drug. Most of the informative and recommendable in vitro - in vivo correlations are those at level A. If the correlation is not possible, a multiple correlation at level C is performed, then those at levels C and B and finally the correlation at level D. The drug dissolution data correlate well with those of drug absorption in the case of establishing the correlation at level A. Although many correlations at levels B and C were weak, good correlations could be also obtained. For immediate release preparations, correlation at level A is recommended. Correlations at level C are appropriate providing especially for preparations with immediate release of the drug, where it is difficult to establish a correlation at level A. Multiple correlations at level C are acceptable and comparable with those at level A IVIVC, but are not suitable for products with immediate release of the drug. |9 eng |
| 530 | |a Dostupné též na internetu (ISSN 1213-7103) | ||
| 546 | |a Český text, anglický abstrakt | ||
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| 650 | 0 | 7 | |a STATISTICAL METHODS |2 agrovoc |
| 650 | 0 | 7 | |a CLASSIFICATION |2 agrovoc |
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| 650 | 0 | 7 | |a permeabilita |2 agrovoc |
| 650 | 0 | 7 | |a řízené uvolňování |2 agrovoc |
| 653 | 0 | |a korelace |a disoluce |a IVIVC | |
| 700 | 1 | |a Kopecká, Marie, |u Lékárna na poliklinice, Svitavy |4 aut | |
| 700 | 1 | |a Vetchá, Martina, |u Lékárna na Mendlově náměstí, Brno |4 aut | |
| 700 | 1 | |a Franc, Aleš, |d 1968- |u VFU Brno, FaF |7 mzk2008479726 |4 aut | |
| 773 | 0 | |t Chemické listy |x 0009-2770 |g Roč. 108, č. 1 (2014), s. 32-39 |q 108:1 |9 2014 | |
| 856 | 4 | 1 | |u http://www.chemicke-listy.cz/docs/full/2014_01_32-39.pdf |q text/pdf |y Plný text |4 N |
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