Směrování léčiv do tlustého střeva = Targeting of Drugs into Colon

Get it

In recent years, drug delivery into colon has gained importance in treatment of colon diseases and systemic absorption of peptide drugs. This review is focused on parameters of the gastrointestinal tract influencing the drug and delivery systems as well as on the main pharmaceutical approaches to colon delivery. The review describes the use of pH-sensitive polymers, polymers biodegradable by colon microflora, azo polymers and other methods resulting in pH-, microbially-, pressure- and time-controlled colon-specific drug delivery systems. The review also covers electronic devices for the purpose. Colon drug delivery offers various therapeutic benefits for patients especially in treatment of local diseases. Its use for systemic drug absorption remains a challenge for future. … full description

Bibliographic Details

Main Author

Kateřina Dvořáčková, 1973-

Other Authors

Aleš Franc, 1968-
Martina Kejdušová, 1982-

Document Type

Articles

Physical Description

Ilustrace

Published in

Chemické listy. -- ISSN 0009-2770. -- Roč. 107, č. 7 (2013), s. 522-529

Subjects

DRUGS

FORMULATIONS

GASTROINTESTINAL AGENTS

INTESTINAL DISEASES

large intestine

Pharmacokinetics

POLYMERS

PH

SOLUBILITY

BIODEGRADABILITY

intestinal flora

PRESSURE

OSMOSIS

TIME

léky

formy

gastrointestinální léčiva

choroby trávicí soustavy

střevní choroby

tlusté střevo

farmakokinetika

polymery

pH

rozpustnost

biodegradabilita

střevní flóra

tlak

osmóza

čas

tobolky > CTDC > Colon Targeted Delivery Capsules > PCDC > Pressure Controlled Drug Capsules > CODES > OROS-CT

Item Description

4 schémata

Bibliography

Literatura na s. 527-528,