Principy uvolňování léčiv z perorálních matricových tablet obsahujících hypromelosu

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Swellable-matrix tablets based on hydrophilic polymers are simple dosage forms with controlled release, which are currently used in pharmacotherapy of many diseases. The most commonly used polymer is (hydroxypropyl)methylcellulose (hypromelose). The drug release from these systems through a gel layer can be modified using additives changing the drug dissolution profile. These excipients can be divided into several groups such as indifferent fillers (soluble or insoluble), substances increasing drug solubility (ß-cyclodextrins), excipients forming interactive products (polymers, ionexchange resins, surfactants) and substances influencing pH in matrix microenvironment (acid and basic modifiers). … full description

Bibliographic Details

Main Author

Kateřina Dvořáčková

Document Type

Articles

Physical Description

6 il.

Published in

Chemické listy. -- ISSN 0009-2770. -- Roč. 103, č. 1 (2009), s. 66-72

Subjects

léčiva

lékové formy

technologie léků

pharmaceuticals

dosage forms

matricové tablety > hypromelosa > řízené uvolňování léčiva

Item Description

5 obrázků, 1 tabulka
Anglické resumé

Bibliography

Literatura